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. 2016 Dec 6;6:38242. doi: 10.1038/srep38242

Figure 3. Subthreshold responses and excitability of DH and VH neurons.

Figure 3

Whole cell recordings from CA1 pyramidal neurons. (a) Resting membrane potential (RMP) was significantly more depolarized for VH (white circles, average: −74.94 ± 1.03 mV, n = 15/8/8) than DH neurons (black circles, average: −79.34 ± 0.81 mV, n = 19/9/9). (b) Voltage responses from DH (upper) and VH (lower) pyramidal cells at RMP to 800 ms step current injections ranging from −50 pA to 50 pA in 10 pA increments. (c) Rin at RMP was significantly higher for VH (white bar, Rin VH = 235.44 ± 19.43 MΩ, n = 18/11/7) than DH cells (black bar, Rin DH = 167.68 ± 15.8 MΩ, n = 14/10/10). (d) Relations between injected current and firing frequency (F–I) for DH (n = 15/9/9) and VH (n = 15/7/7) pyramidal cells. Differences between F-I curves were statistically significant at 50 pA. *Indicates p < 0.05. **Indicates p < 0.01.