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. 2016 Dec 6;6:38128. doi: 10.1038/srep38128

Table 5. Predicted toxicity risk parameters of benzo[h]quinolines.

Compound Reproductive/developmental toxicity Ames test TOPKAT skin irritancy TOPKAT Ames score TOPKAT rat oral LD50 (mg/kg) TOPKAT rat carcinogenic potency TD50 (mg/kg)
3a Non-Toxic Mutagen Non-Irritant 4.52304 0.193812 3.84699
3b Non-Toxic Mutagen Non-Irritant 0.925525 0.229992 1.03367
3c Toxic Non-Mutagen Non-Irritant −0.762268 0.236661 1.06625
3d Toxic Mutagen Non-Irritant 3.26021 0.159558 0.531709
3e Non-Toxic Mutagen Non-Irritant 4.41803 0.197063 0.8887
3f Non-Toxic Mutagen Non-Irritant 3.89661 0.184627 1.06061
3g Non-Toxic Mutagen Non-Irritant 1.38151 0.131322 1.14982
3h Non-Toxic Mutagen Non-Irritant 2.43415 0.377348 0.472136
3i Toxic Mutagen Non-Irritant 0.450189 0.51522 0.486793
3j Toxic Mutagen Non-Irritant 4.8735 0.281606 0.242827
Doxorubicin Toxic Mutagen Non-Irritant 23.0401 0.192388 0.756873