Table 2. Kinetic and inhibition constants for wt and mutant DrUox.
| Urate |
Xanthine | |||
|---|---|---|---|---|
| KM (μM) | kcat (s−1) | kcat/Km (M−1 s−1) | Ki (μM) | |
| Wild Type | 11 ± 1 | 3.95 ± 0.09 | 3.6 * 105 | 4.3 ± 0.27 |
| F216S | 284 ± 31 | 3.99 ± 0.1 | 1.4 * 104 | 59.2 ± 8.2 |
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