Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Dec 6;6:38285. doi: 10.1038/srep38285

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Left panel: Chronic morphine infusion sets up a cascade of events that lead to decreased levels of miR-365 and increased expression of β-arrestin 2, which ultimately causes morphine tolerance. Right panel: After a host cell is infected with a lentivirus, the viral genome is integrated into the host genome in the nucleus to yield primary-miR-365. Primary-miR-365 is processed to yield premature-miR-365, which is exported to the cytoplasm where mature miR-365 is generated and incorporated into the RISCs that are programmed by microRNA. This leads to inhibition of expression of host mRNAs (β-arrestin 2) in the cytoplasm of the infected cell. Decreased expression of β-arrestin 2 attenuates morphine tolerance. RISC = RNA-induced silencing complex, miR = microRNA.