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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Eur J Immunol. 2016 Sep 6;46(10):2352–2362. doi: 10.1002/eji.201646354

Figure 3. SIRPα+ DC are increased in the 4 wk-old thymus and exhibit enhanced T cell stimulatory capacity.

Figure 3

Expression of (A) co-stimulatory and (B) MHC molecules by NOD newborn and 4 wk-old thymic DC; data ± SEM are the average of ≥4 separate experiments. (C) Frequency of NOD newborn and 4 wk-old thymic DC subsets (n=7 mice). (D) T cell stimulation by newborn versus 4 wk-old thymic DC subsets sorted from NOD mice, injected with 10 μg sBDC, and cultured with CFSE-labeled NOD.BDC CD4+ T cells; data ± SEM are the average of 12 separate samples. *p<0.05 (paired Student’s t-test).