FIG. 3.

Metabolic pathway enrichment analysis (MetPA) of urinary metabolites altered by TCDD (P ≤ 0.05). Pathway alterations were considered significant when enrichment values (pathway over-representation) ≥ 4.0. Impact scores (connectedness of altered metabolites) were used to rank pathways most affected by TCDD treatment (Supplementary Tables 4 and 6).