FIG. 8.

Effect of catalytic antioxidant treatment on SM-induced early airway cast formation. Following microdissection, airway sections were scored for percent occlusion, which was converted to a weighted score. Cast scores were evaluated at 6, 12, 18, and 24 h post-exposure to evaluate cast formation over time with or without (q4 hours) antioxidant administration. Data is presented as mean ± SEM. Two-way ANOVA with Bonferroni’s multiple comparisons test was performed to determine differences between groups over time where * indicates significantly different from SM +PBS (P < .05). SM PBS 6 h n = 5, SM PBS 12 h n = 5, SM PBS 18 h n = 6, SM PBS 24 h n = 6, SM 10150 6 h n = 5, SM 10150 12 h n = 5, SM 10150 18 h n = 6, SM 10150 24 h n = 7.