FIG. 1.

Activation of the coagulation cascade in livers of male wild-type mice gavaged with sesame oil vehicle or 30 µg/kg TCDD every 4 days for 28 days. (A) Plasma thrombin antithrombin (TAT) levels are represented as mean + SEM for N = 6 (vehicle) or N = 8 (TCDD). (B) Overview of the coagulation cascade describes the relationship between fibrin deposition and activation of the protease activated receptor-1 (PAR-1) describing the pathway being investigated in response to TCDD exposure. (C) Representative photomicrographs of liver sections stained for fibrin(ogen) (red) in vehicle and TCDD-treated mice. Asterisks indicate a significant difference (P ≤ 0.05) determined by Student’s t-test and scale bars represent 50 µm.