FIG. 5.

TCDD-elicited changes in serum (A) IFN-γ, (B) IL-10, (C) IL-6, (D) TNFα, and (E) IL-5 levels in male wild-type (PAR-1^+/+) and PAR-1^−/− mice gavaged with sesame oil vehicle or 30 µg/kg TCDD every 4 days for 28 days. Bars represent mean + SEM for N = 4 (PAR-1^+/+vehicle), 5 (PAR-1^+/+TCDD), 3 (PAR-1^−/− vehicle) and 6 (PAR-1^−/− TCDD). Lines with an asterisk (*) indicate a significant difference (P ≤ 0.05) within and/or between genotype determined by 2-way ANOVA followed by Student–Newman–Keul’s post hoc test.