FIG. 6.

Hepatic collagen deposition in male mice gavaged with sesame oil vehicle or 30 µg/kg TCDD every 4 days for 28 days. (A) Representative photomicrographs of liver sections stained with PicroSirius Red (PSR) in wild-type and PAR-1^−/− vehicle and TCDD-treated mice. Scale bars represent 50 µm. (B) Quantitation of PSR staining is represented as mean + SEM for N = 5 (PAR-1^+/+vehicle), 3 (PAR-1^+/+TCDD), 4 (PAR-1^−/− vehicle) and 4 (PAR-1^−/− TCDD). Lines with an asterisks (*) above indicates a significant difference (P ≤ 0.05) within and/or between genotype determined by 2-way ANOVA followed by Student–Newman–Keul’s post hoc test.