TABLE 1.

Synopsis of Studies Conducted for Describing EH-TBB Disposition

	Dose (µmol/kg), route, species
	0.1, IV, rat	0.1, oral, rat	0.1, oral, mouse	1, oral, rat	10, oral, rat	100, oral, rat
Dose number, duration		Single, 1 h
		Single, 4 h
		Single, 8 h
		Single, 24 h	Single, 24 h
		Single, 24 h, JVC
		Single, 24 h, BDC
	Single, 72 h	Single, 72 h		Single, 72 h	Single, 72 h	Single, 72 h
		Repeat x 5, 24 h
		Repeat x 5, 72 h
		Repeat x 10, 24 h
		Repeat x 10, 72 h

Studies were primarily conducted in female SD rats. N = 4 animals per study unless otherwise noted. JVC: jugular vein cannulated; BDC: bile duct cannulated.