TABLE 3.

[¹⁴C]-Radioactivity Recovered in Excreta and Major Tissues after Oral Administration of EH-TBB (0.1 µmol/kg) to Female SD Rats or Male B6C3F1/Tac Mice

Tissue	Dose recovered	Single	Single	Single	Single	Single (mouse)	Repeated
		1 h	4 h	8 h	24 h	24 h	24 h
Feces	%	0.2 ± 0.2a	16 ± 8	42 ± 11	49 ± 13b	49 ± 14b	29 ± 3c
Urine	%	0.3 ± 0.2	5 ± 2	19 ± 3	43 ± 13b	47 ± 14b	65 ± 4c
Stomach contents	%	30 ± 9	13 ± 5	3 ± 1	n.d.	n.d.	n.d.
Small intestine contents	%	46 ± 19	20 ± 6	5 ± 2	n.d.	n.d.	n.d.
Blood	%	6 ± 1	13 ± 5	10 ± 3	1 ± 0.5	0.6 ± 0.3	0.3 ± 0.1
	(pmol-eq/g)	(4 ± 1)	(9 ± 4)	(7 ± 2)	(0.001 ± 0.001)	(0.0003 ± 0.0001)	(0.4 ± 0.1)
Liver	%	2 ± 1	5 ± 2	3 ± 0.3	0.3 ± 0.1	0.1 ± 0.2	0.1 ± 0.02
	(pmol-eq/g)	(43 ± 26)	(104 ± 51)	(77 ± 3)	(8 ± 4)	(2 ± 2)	(6 ± 1)
Adipose	%	2 ± 2	2 ± 1	2 ± 2	0.6 ± 0.4	0.5 ± 0.5	0.6 ± 0.1
	(pmol-eq/g)	(15 ± 15)	(22 ± 12)	(22 ± 16)	(7 ± 4)	(3 ± 3)	(11 ± 1)
Muscle	%	2 ± 0.5	7 ± 4	4 ± 2	0.2 ± 0.2	0.1 ± 0.1	0.6 ± 0.3
	(pmol-eq/g)	(6 ± 3)	(13 ± 8)	(10 ± 4)	(0.4 ± 0.4)	(0.2 ± 0.1)	(3 ± 2)
Kidney	%	2 ± 0.6	4 ± 1	3 ± 0.5	0.4 ± 0.1	0.7 ± 0.5	0.1 ± 0.0
	(pmol-eq/g)	(226 ± 89)	(547 ± 202)	(427 ± 106)	(59 ± 19)	(41 ± 20)	(37 ± 11)
Skin	%	1 ± 0.6	6 ± 2	4 ± 0.7	0.6 ± 0.5	0.2 ± 0.2	0.4 ± 0.1
	(pmol-eq/g)	(9 ± 3)	(37 ± 19)	(31 ± 6)	(5 ± 3)	(1 ± 1)	(6 ± 1)
Lung	%	0.4 ± 0.6	0.5 ± 0.2	0.5 ± 0.2	0.05 ± 0.03	0.03 ± 0.02	0.02 ± 0.006
	(pmol-eq/g)	(57 ± 63)	(83 ± 42)	(76 ± 20)	(8 ± 5)	(3 ± 1)	(6 ± 2)
Brain	%	0.2 ± 0.0	0.1 ± 0.0	0.0 ± 0.0	0.003 ± 0.01	0.003 ± 0.003	0.007 ± 0.004
	(pmol-eq/g)	(2 ± 1)	(6 ± 2)	(3 ± 2)	(0.5 ± 1)	(0.2 ± 0.2)	(2 ± 1)

^aEach value represents the mean ± SD of 4 animals per treatment group.

^bSignificantly different from repeat dose (rat, 24 h), P < .001.

^cSignificantly different from single dose (rat, 24 h), P < .0001.

n.d.: not determined.