Table 1.
All | MS | HSP/HA | |
---|---|---|---|
Number (%) | 168 (100) | 91 (54.4) | 77 (45.6) |
Women (%) | 82 (48.8) | 46 (50.5) | 36 (46.8) |
Disease phenotype (%) | RRMS 51 (56.0) SPMS 34 (37.4) PPMS 6 (6.6) |
HSP 61 (79.2) HA 12 (15.6) HSP w/ataxia 4 (5.2) |
|
Age (SD) | 55.3 (±10.4) | 52.0 (±10.3) | 52.7 (±10.6) |
Disease duration >20 years (%) | 93 (55.4) | 46 (50.5)a | 47(61.0) |
Years since onset (SD) | 24.2 (±12.8) | 21.3 (±9.0)a | 27.7 (±15.4) |
Disability (SD) | |||
No aid | 84 (50.0) | 49 (53.8) | 35 (45.5) |
One or two sticks | 65 (38.7) | 31 (34.1) | 34 (44.2) |
In wheel chair | 19 (11.3) | 11 (12.1) | 8 (10.4) |
EDSS | 4.9 (median 5.0, range: 1.5-8.0) | ||
Height, cm (SD) | 172.7 (±8.6) | 173.2 (±8.3) | 172.1 (±8.9) |
Weight, kg (SD) | 74.3 (±16.3) | 71.8 (±14.1)a | 77.2 (±18.2) |
BMI Kg/m2 (SD) | 24.8 (±4.5) | 23.9 (±4.2)a | 25.8 (±4.7) |
Total body fat % (SD) | 32.3 (±8.5) | 31.6 (±8.5) | 33.0 (±8.5) |
Abbreviations: EDSS Expanded Disability Status Scale, RRMS relapsing remitting multiple sclerosis, SPMS secondary progressive multiple sclerosis, PPMS primary progressive multiple sclerosis, HSP hereditary spastic paraplegia, HA hereditary ataxia, BMI body mass index
a p <0.05 (independent sample t-test) compared to patients with HSP/HA