Table 3.
Pain medication during the study (safety analysis set)
| Pain medicationa | Capsaicin 8% patch (30 min) + SOC (n = 156) |
Capsaicin 8% patch (60 min) + SOC (n = 157) |
SOC (n = 155) |
|---|---|---|---|
| Overall, n (%) | 98 (62.8) | 105 (66.9) | 107 (69.0) |
| Most commonly used category (>10 % patients in either group), n (%) | |||
| Analgesicsb | 79 (50.6) | 84 (53.5) | 81 (52.3) |
| Antiepileptics | 54 (34.6) | 57 (36.3) | 73 (47.1) |
| Topical products for joint and muscular pain | 30 (19.2) | 35 (22.3) | 29 (18.1) |
| Anti-inflammatory/antirheumatic products | 29 (18.6) | 35 (22.3) | 30 (19.4) |
| Psycholeptics | 24 (15.4) | 22 (14.0) | 40 (25.8) |
| Stomatological preparations | 18 (11.5) | 22 (14.0) | 18 (11.6) |
| Psychoanaleptics | 16 (10.3) | 6 (3.8) | 21 (13.5) |
| Ophthalmologicalsc | 15 (9.6) | 20 (12.7) | 16 (10.3) |
| Most commonly used drugs (>5% patients in any group), n (%) | |||
| Gabapentin | 26 (16.7) | 26 (16.6) | 35 (22.6) |
| Pregabalin | 24 (15.4) | 22 (14.0) | 39 (25.2) |
| Paracetamol | 23 (14.7) | 36 (22.9) | 6 (3.9) |
| Tramadol | 16 (10.3) | 14 (8.9) | 6 (3.9) |
| Diclofenac | 12 (7.7) | 13 (8.3) | 12 (7.7) |
| Ibuprofen | 11 (7.1) | 15 (9.6) | 14 (9.0) |
| Metamizole | 10 (6.4) | 10 (6.4) | 5 (3.2) |
| Duloxetine | 9 (5.8) | 3 (1.9) | 10 (6.5) |
| Carbamazepine | 7 (4.5) | 14 (8.9) | 10 (6.5) |
| Alpha lipoic acid | 3 (1.9) | 1 (0.6) | 8 (5.2) |
SOC standard of care
aMedication used for pain (check box of ‘pain medication’ is YES on electronic case report form [eCRF])
bAnalgesics were categorised by class: anilides, natural opium alkaloids, other analgesics and antipyretics, other opioids, pyrazolones, and salicylic acid and derivatives
cOphthalmologicals (eye treatments) were categorised by anti-inflammatory agents and nonsteroids, local anaesthetics, corticosteroids (plain) and other ophthalmologicals