Fig. 3.

A 1 bp deletion in exon 9 of MOCOS associated with renal syndrome (xanthinuria) in Tyrolean Grey cattle. a MOCOS gene and its position on bovine chromosome24. Note the two alternative first exons (1a and 1b), leading to the alternate transcripts (MOCOS-201 and MOCOS-202, shown in Fig. 6). b Screenshot of the next generation sequencing reads mapped against the reference sequence. Note the C deletion in exon 9. c Electropherograms of a control Tyrolean Grey cattle (wild type), a parent of one of the affected twins (heterozygous carrier), and one affected case (homozygous). The arrow indicates the position of the 1 bp deletion