Fig. 6.

Summary of known bovine and human MOCOS mutations. a The two bovine MOCOS transcripts (MOCOS-201 and MOCOS-202) are shown (center). The position of the mutation detected in Tyrolean Grey cattle is indicated. The two possible wild type proteins and the relevant domains (AAT: aspartate aminotransferase; MBB: mosc beta barrel; MOSC: MOSC domain) are shown above. Below, the two predicted mutant proteins are shown. Note the predicted mutant truncated proteins lack MBB and MOSC domains. b Previously reported mutations causing xanthinuria in human and cattle are displayed (JB: Japanese Black cattle; TG: Tyrolean Grey cattle). The nature of the predicted mutation effect of the protein is shown. The positions of mutated bovine residues are aligned to the length of the human protein