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. 2016 Aug 13;21(8):1058. doi: 10.3390/molecules21081058

Table 1.

Reduction conditions of 7-benzyloxy-5,6-dimethoxy-4-chromenone (12).

graphic file with name molecules-21-01058-i001.jpg

Entry Condition Yield (%) a
16 13 17
1 H2, Pd/C, MeOH, rt - b 99 -
2 NaBH4 (1.5 eq), EtOH, rt - - <10
2 NaBH4 (2.5~5.0 eq), EtOH, rt - - 50
3 DIBAL c (1.0 eq), THF:toluene (1:1), −60 °C 20 - 20
4 LiAlH4 (2.0 eq), THF:Et2O (1:1), −60 °C 99 - -

a Isolated yield; b not found; c diisobutylaluminum hydride.