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S. flexneri 2a LPS-specific serum IgG (a) and IgA (b) responses. ELISA endpoint titers over time are shown for day 0 (baseline), day 28 (post-first vaccination), and day 56 (post-second vaccination), with geometric means. §, statistically significantly different from baseline samples; *, statistically significantly different from placebo at the same time point.
