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. 2016 Sep 26;5(11):e1235108. doi: 10.1080/2162402X.2016.1235108

Figure 5.

Figure 5.

Impact of polymorphisms in FCGR2A and -3A genes on event-free survival of neuroblastoma patients (n = 53) treated by long-term infusion of ch14.18/CHO. Validated detection of FCGR2A and -3A polymorphisms was performed to identify high- and low-affinity patient cohorts. (A) Impact of FCGR2A high (H/H or H/R genotype; black line) and low affinity (R/R; gray line) on EFS. (B) Impact of FCGR3A high (V/V or V/F genotype; black line) and low affinity (F/F; gray line) on EFS. (C) Analysis of combined FCGR2A and -3A high (FCGR2A H/H or H/R and FCGR3A V/V or V/F; black line) and low-affinity genotypes (FCGR2A R/R or FCGR3A F/F; gray line) on EFS. Statistical analysis was performed using LogRank test.