Figure 4.

Recognition of primary human tumors expressing shared T-cell epitopes by BCR peptide-specific CD4⁺ Tcells. (A) IFNγ ELISA assay of allogeneic or (B) autologous BCR peptide-specific CD4⁺ T cells stimulated with mantle cell lymphomas (MCL) expressing the same epitopes and HLA DRB1 alleles. (C) Cytotoxic assay of autologous BCR peptide-specific CD4⁺ T cells stimulated with mantle cell lymphomas (MCL) expressing the same epitopes and HLA DRB1 alleles. Data are representative of three individual experiments.