Table 1.

Shared specificity and characteristics of BCR CD4⁺ T-cells epitopes.

Types	Peptides	Subfamily and regiona	Sequence	Length	HLA DR binding	Sharedb	Shared (%)	Total shared (%)
Normal donors	VH P60-1	IGHV3-16FR2	MNWARKAPGKGLEWV	15	1101, 0301	0/64	0.0	VH 23/64 (36%)
	VH P60-2	IGHV3-16FR2	NWARKAPGKGLEWVS	15	1101, 0301	0/64	0.0
	VH P60-3	IGHV3-16FR2	WARKAPGKGLEWVSG	15	1101, 0301	0/64	0.0
	VH P106-2	IGHV3-11FR3	KNSLYLQMNSLRAED	15	0401, 1101, 0701	2/64(VH)	3.1
	VH P106-4	IGHV3-11FR3	SLYLQMNSLRAEDTA	15	0401, 1101, 0701	2/64(VH)	3.1
	VH P106-8	IGHV3-11FR3	GRFTISRDNAKNSLY	15	0401, 1101, 0701	4/64(VH)	6.3
	VH P106-11	IGHV3-11FR3	QMNSLRAEDTAVYYC	15	0401, 1101, 0701	3/64(VH)	4.6
	VH P121-3	IGHV3-74FR3	AKNTLYLQMNSLRAE	15	0301, 1101	0/64	0.0
	VHP121-10	IGHV3-74FR3	DSVKGRFTISRDNAK	15	0301, 1101	5/64(VH)	7.8
	VHP125-13	IGHV4-30-2FR3	FSLKLSSVTAADTAV	15	0101, 0301	2/64(VH)	3.1
Patients	FL1VH17	IGHV4-34FR3	SRLTISVDTSKNQFS	15	0701, 1501, 0801,101	0/64	0.0
	FL2VH3	IGHV4 FR1	PGLVKPSETLSLTCT	15	1101, 0701, 0801,0101,1 501,1301	3/64(VH)	4.7
	FL2VH4	IGHV4CDR1	KPSETLSLTCTVSGG	15	1101, 0701,0801,0101, 1501,1401	2/64 (VH)	3.1
	FL1VL5	IGLV1CDR1	RVTISCSGSTSNIGS	15	0701	0/90	0.0	VL 7/90 (7.8%)
	SMZL1VL1	IGLV1FR1	QSVLTQPPSASGTPGQ	16	0301, 0401	7/90(VL)	7.8
	PL1VK12	IGKV3 CDR1	YLAWYQQKPG	10	0701,1401,0801	20/123 (VK)	16.3	VK 20/123 (16.3%)
Normal donors	VK P14-5	IGKV2-24FR1	QTPLSSPVTLGQPAS	15	1101, 0801, 0701,1301	0/123	0.0

^aAnalysis and blast by IMGT Web site (http://imgt.cines.fr/IMGT_vquest/vquest?livret=0&Option=humanIg).

^bIndividual peptide sequences were compared with Ig V region sequences available from either 64 FL patients with VH chain, 90 FL patients with l light chain, or 123 patients with k light chain isotype, respectively.