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. 2016 Sep 9;5(11):e1232235. doi: 10.1080/2162402X.2016.1232235

Figure 3.

Figure 3.

LMW-HA disrupts lymphatic endothelial cell barrier function and increases melanoma cell migration across the lymphatic endothelium. (A) Effects of LMW-HA (10 µg/mL), HMW-HA (10 µg/mL), VEGF-A (100 ng/mL), and medium on lymphatic endothelial barrier function were measured by transendothelial electrical resistance (TEER) in HDLECs (n = 3). The arrows indicate the times of addition. (B, C) Cumulative data regarding the numbers of B16F10 (B) and A375 (C) cells that migrated through the lymphatic endothelial cell monolayer were calculated, n = 3, *p < 0.05, **p < 0.01, ***p < 0.001, ANOVA.