Table 1.
Clinical characteristics and bone parameters of InCHIANTI population.
| Men (n=451) | Women (n=508) | p | |
|---|---|---|---|
| Age (yrs) (mean±SD) | 66.7±15.1 | 68.0±15.2 | ns |
| Body Mass Index (kg/m2) (mean±SD) | 26.9±3.4 | 27.3±4.7 | ns |
| Previous hip fractures (n, %) | 7 (1.6) | 8 (1.6) | ns |
| Physical activity | <0.0001 | ||
| Sedentary (n, %) | 40 (8.9) | 101 (19.9) | |
| Light (n, %) | 351 (77.8) | 384 (75.6) | |
| Moderate/High (n, %) | 60 (13.9) | 23 (4.5) | |
| Calcium intake (g/die) | 893.0±324.7 | 840.1±338.2 | <0.0001 |
| Smokers (n, %) | 99 (22.0) | 58 (11.4) | <0.0001 |
|
| |||
| CBA (mm2) (mean±SD) | 331.2 (48.2) | 273.7 (54.3) | <0.0001 |
| Ct.Th. (mm) (mean±SD) | 5.3 (1.0) | 4.3 (1.1) | <0.0001 |
| BMDt (mg/cm3) (mean±SD) | 225.7 (54.8) | 202.5 (59.7) | <0.0001 |
| BMDc (mg/cm3) (mean±SD) | 1027.0 (58.0) | 998.6 (73.9) | <0.0001 |
|
| |||
| LRP5 genotype (A1330V) | |||
| CC (n, %) | 351 (78%) | 379 (75%) | |
| CT (n, %) | 89 (20%) | 122 (24%) | |
| TT (n, %) | 11 (2%) | 7 (1%) | |
|
| |||
| LRP5 genotype (Val667Met) | |||
| GG (n, %) | 392 (87%) | 432 (85%) | |
| GA (n, %) | 59 (13%) | 74 (14.5%) | |
| AA (n, %) | - | 3 (0.5%) | |