Table 4.
Association between LRP5 gene polymorphism and bone parameters in older men and women.
| Dependent Variable vBMDt
|
Dependent Variable vBMDc
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Men
|
Women
|
Men
|
Women
|
|||||
| b (SE) | p | b (SE) | p | b (SE) | p | b (SE) | p | |
|
| ||||||||
| LRP5 (TT vs CC) | −7.11 (5.08) | 0.16 | −1.04 (5.58) | 0.85 | 0.57 (5.72) | 0.92 | −3.31 (6.12) | 0.59 |
| LRP5 (AA vs GG) | −15.1 (8.2) | 0.07 | −2.2 (7.8) | 0.78 | −12.1 (9.1) | 0.18 | −1.0 (9.0) | 0.91 |
| Dependent Variable CBA
|
Dependent Variable Ct.Th
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Men
|
Women
|
Men
|
Women
|
|||||
| b (SE) | p | b (SE) | p | b (SE) | p | b (SE) | p | |
|
| ||||||||
| LRP5 (TT vs CC) | 5.92 (4.71) | 0.20 | −9.21 (4.73) | 0.04 | 0.08 (0.10) | 0.44 | −6.22 (4.78) | 0.19 |
| LRP5 (AA vs GG) | −10.8 (7.6) | 0.16 | −13.8 (5.5) | 0.01 | −0.15 (0.16) | 0.35 | 0.13 (0.13) | 0.3 |
Parsimonious models obtained by backward selection method from initial models including age, BMI, cross-sectional muscle area, levels of physical activity and serum bioavailable testosterone, estradiol, Vit-D and PTH.