Table 3. RECQL5 Colon Cancer Haplotype Association Tests.
| rs820196-rs4789223 haplotypea | Case frequency | Control frequency | OR (95% CI), p-value | Adjusted OR (95% CI),b p-value |
|---|---|---|---|---|
| T-A (common alleles) | 0.57 | 0.61 | 1.0 (reference) | 1.0 (reference) |
| C-G (2 minor alleles) | 0.23 | 0.23 | 1.13 (0.83, 1.37), 0.62 | 1.13 (0.87, 1.47), 0.72 |
| T-G | 0.20 | 0.16 | 1.34 (1.02, 1.76), 0.05 | 1.39 (1.04, 1.87), 0.04 |
a
C-A haplotype too rare to consider; frequency of 0.001 in cases, absent in controls.
b
Adjusted for age, sex, BMI, NSAID use and family history of colorectal cancer.