Table 2. Serum Levels of Biochemical Markers in the Studied Groups.
| Marker | HBV n = 12 |
HCV n = 29 |
Bilharziasis n = 9 |
All Patients n = 50 |
Controls n = 30 |
P-valuea | P-valueb |
|---|---|---|---|---|---|---|---|
| TGF-β1 (ng/ml) | 61.7 ± 4.9 | 68.7 ± 2.6 | 65.5 ± 5.29 | 66.504 ± 2.14 | 50.9 ± 2.2 | 0.000** | 0.000** |
| EGF-R (ng/ml) | 0.904 ± 0.1 | 0.929 ± 0.1 | 1.2 ± 0. 19 | 0.97 ± 0.07 | 0.88 ± 0.05 | 0.315 | 0.699 |
| Collagen IV (ng/ml) | 211.1 ± 19.4 | 224.9 ± 14.3 | 226.1 ± 29.5 | 221.8 ± 10.7 | 85.6 ± 3.6 | 0.000** | 0.000** |
| Laminin (ng/ml) | 57.0 ± 4.8 | 68.9 ± 2.5 | 57.5 ± 6.6 | 64.05 ± 2.3 | 45.5 ± 2.4 | 0.000** | 0.000** |
| MMP-2 (ng/ml) | 849.3 ± 31.3 | 787.6 ± 33.6 | 762.2 ± 79.8 | 797.87 ± 25.18 | 653.4 ± 18.3 | 0.000** | 0.000** |
a
Significance was tested between all patients (n = 50) versus controls (n = 30) using Mann-Whitney test.
b
Significance was tested among individual etiological (HBV, HCV and Bilharziasis) groups and controls using Kruskal-Wallis test.
** P < 0.01. Values are expressed as mean ± standard error of mean (SEM).