Table 4. Diagnostic Performance of Serum Biochemical Markers in Predicting Significant Fibrosis and Cirrhosis in Chronic Hepatitis B and C Patients.
| Marker | AUROC | P-value | Cut-off | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|---|---|
| Significant Fibrosis (Ishak score > 2) | |||||||
| TGF-β1 | 0.74 | 0.01** | 54.8 | 78.6 | 71.4 | 73.3 | 76.9 |
| Collagen IV | 0.94 | 0.000** | 132.5 | 92.9 | 91.4 | 91.5 | 92.8 |
| Laminin | 0.82 | 0.001** | 60.9 | 71.4 | 77.1 | 75.7 | 72.9 |
| MMP-2 | 0.77 | 0.004** | 742 | 85.7 | 71.4 | 74.9 | 83.3 |
| Cirrhosis (Ishak score 6) | |||||||
| TGF-β1 | 0.7 | 0.089 | 57.5 | 85.7 | 66.6 | 72 | 82.3 |
| Collagen IV | 0.85 | 0.003** | 147.5 | 85.7 | 78.6 | 80 | 85.1 |
| Laminin | 0.76 | 0.031* | 63.7 | 71.4 | 81 | 78.9 | 73.9 |
| MMP-2 | 0.68 | 0.126 | 747 | 85.7 | 64.3 | 70 | 81.8 |
*P ≤ 0.05, **P ≤ 0.01