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. 2016 Nov 21;18(23):5974–5977. doi: 10.1021/acs.orglett.6b02569

Scheme 2. 13C Label from (2-13C)-5 Is Specifically Incorporated into 1 via Metabolically Engineered Bacteria.

Scheme 2

13C-labeled 1 can then be incubated with bacteria recombinantly co-expressing CYP114 and FdGA to produce 13C-labeled 3.