Table 4.
Acquisition costs for ceftolozane/tazobactam, ceftazidime/avibactam, and comparator agents
| Drug | AWP price (USD) | AWP unit | Standard dosing for cIAI | cIAI treatment cost per day (USD) |
|---|---|---|---|---|
| Novel agents | ||||
| Ceftolozane/tazobactam | ≥104.48 | 1.5 ga | 1.5 g Q8Ha | ≥313.44b |
| Ceftazidime/avibactam | ≥359.10 | 2.5 ga | 2.5 g Q8Ha | ≥1,077.30b |
| Comparator agents | ||||
| Ceftriaxone | ≥0.34 | 1 g | 1 g Q24H | ≥0.34b |
| Cefepime | ≥0.51 | 2 g | 2 g Q8H | ≥1.53b |
| Piperacillin/tazobactam | ≥8.31 | 4.5 g | 4.5 g Q6H | ≥33.24 |
| Meropenem | ≥26.40 | 1 g | 1 g Q8H | ≥79.20 |
Notes:
a
Total dose of cephalosporin and β-lactamase inhibitor.
b
Does not include the negligible cost of added metronidazole therapy. Data from Red Book Online.88
Abbreviations: AWP, average wholesale price; cIAI, complicated intra-abdominal infection; USD, United States dollars.