Fig 2. Somatic mutations in three LUAD candidate driver genes (POU4F2, ZKSCAN1, and ASEF) in EAGLE, TCGA and Broad Institute studies.

The protein sequences from these three genes are schematically described using grey bars along with their respective structural and functional domains in color-coded blocks. Each mallet represents an independent nonsilent mutation with potential functional relevance in the three studies (the complete list of mutations is reported in S1 Table). Numbers below each sequence representation mark the total length of the transcript, the domain ranges, and the locations of mutations.