Table 1. Effect of Deletions of RRM3, RAD5, RDH54 on Accumulation of Gross-Chromosomal Rearrangements in the Presence or Absence of Genotoxic Agents.
| Relevant Genotype | GCR Rate | |||||
|---|---|---|---|---|---|---|
| Canr 5-FOAr x 10−10 (95% CI) | ||||||
| Untreated | + HU | + MMS | ||||
| wildtype | 1.1 | (<1–6.1) | 20 | (9.6–35) | 65 | (55–75) |
| rrm3Δ | 14 | (11–27) | 139 | (106–171) | 97 | (90–114) |
| rad5Δ | 237 | (220–271) | 1477 | (1300–1590) | 928 | (837–1020) |
| rrm3Δ rad5Δ | 260 | (224–263) | 1600 | (1390–1680) | 1040 | (834–1220) |
| rdh54Δ | 17 | (11–27) | 191 | (144–212) | 108 | (87–135) |
| rrm3Δ rdh54Δ | 25 | (14–54) | 202 | (194–224) | 120 | (99–266) |
| rad5Δ rdh54Δ | 263 | (244–272) | 1578 | (1320–1710) | 991 | (907–1160) |
| rrm3Δ rad5Δ rdh54Δ | 322 | (278–419) | 2446 | (2140–2670) | 1664 | (1350–1810) |