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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Cancer Discov. 2016 Sep 28;6(11):1230–1236. doi: 10.1158/2159-8290.CD-16-0575

Figure 1.

Figure 1

Presentation and progression of glioblastoma with PNET features in an adult patient. A) A left frontoinsular enhancing tumor was identified at presentation and resected. Following concomitant temozolomide and radiation treatment, an intradural/extramedullary C7-T2 metastasis was identified and also resected. Following a course of Pembrolizumab, a second intradural/extramedullary metastasis at T7-8 was resected. All tumors were glioblastoma with PNET features. (B) Mutational burden as detected by whole exome DNA sequencing. Each tumor harbored between 9–11,000 non-synonymous mutations. (C) All tumors carried a nearly identical spectrum of mutations, with the majority C>G alterations. (D) Relative expression of MGMT by RNA-seq across each tumor.