Table 4.

Proportional hazards regression modeling of risk of developing metabolic abnormalities associated with type of ART regimen received

	Total cholesterol		HDL cholesterol		LDL cholesterol		Triglycerides
Covariate	HR (95% CI)1	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
Type of ART regimen:
PI-containing	1.6 (0.5–5.7)	0.46	0.6 (0.2–1.5)	0.27	1.5 (0.4–5.4)	0.56	3.6 (1.3–10.5)	0.0167
Non-PI-containing	0.6 (0.1–2.8)	0.52	0.4 (0.1–1.3)	0.12	0.6 (0.1–2.8)	0.52	1.5 (0.5–4.5)	0.51
No ART	1.0		1.0		1.0		1.0
Age (1-year increase in age)	1.0 (0.9–1.2)	0.82	1.1 (0.9–1.3)	0.26	0.9 (0.8–1.1)	0.32	1.1 (1.0–1.2)	0.22
Gender:
Male	1.4 (0.7–2.9)	0.30	0.7 (0.3–1.3)	0.25	0.7 (0.4–1.6)	0.44	0.5 (0.3–0.8)	0.0029
Female	1.0		1.0		1.0		1.0
Country:
Brazil	0.5 (0.3–1.1)	0.0745	0.7 (0.3–1.6)	0.46	1.2 (0.5–2.9)	0.70	0.3 (0.2–0.5)	<0.0001
Mexico/Peru	1.0		1.0		1.0		1.0
HIV RNA:
≥400 copies/mL	0.4 (0.2–0.9)	0.0178	1.2 (0.6–2.6)	0.57	0.4 (0.2–1.0)	0.0376	0.7 (0.5–1.2)	0.21
<400 copies/mL	1.0		1.0		1.0		1.0
CD4%:
≤25%	-	-	2.5 (1.2–5.0)	0.0128	-	-	-	-
>25%			1.0

¹HRs (hazard ratios) and 95% confidence intervals (95% CI) obtained from proportional hazards regression modeling.