Table 3.
Association between >10% emphysema with symptoms and 6-minute walk distance (6MWD) in HIV-infected (HIV+) and HIV-uninfected (HIV−) subjects
| Characteristic | Unadjusted Analysis | Adjusted Analysisc |
|---|---|---|
| HIV+ (n=169) | ||
| Chronic cough and/or phlegma | 2.7 (1.2, 5.9) | 2.6 (1.0, 6.7) |
| SOBa | 1.8 (0.89, 3.7) | 1.5 (0.59, 3.9) |
| 6MWD, mb | −33 (−59, −6.2) | −35 (−64, −6.6) |
| HIV− (n=153) | ||
| Chronic cough and/or phlegma | 0.87 (0.37, 2.1) | 0.44 (0.15, 1.4) |
| SOBa | 0.92 (0.35, 2.4) | 0.96 (0.26, 3.5) |
| 6MWD, mb | + 12 (−31, 55) | +27 (−21, 77) |
a
Odds Ratios (95% CI) from separate logistic regression models comparing the association between >10% emphysema with a) chronic cough and/or phlegm, or b) exertional shortness of breath (SOB)
b
Beta-coefficient from linear regression model comparing the association between >10 emphysema with increase (+) or decrease (−) (95% CI) in 6 minute walk distance (6MWD) in meters
c
All models adjusted for sex, race, age, BMI, pack years smoking, CD4 count (if HIV+), drug use and chronic illnesses (chronic heart disease, diabetes, hypertension, anemia)