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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Mol Biochem Parasitol. 2016 Jul 19;209(1-2):88–103. doi: 10.1016/j.molbiopara.2016.07.003

Figure 2. Function of select membrane-trafficking machinery in a model endomembrane system.

Figure 2

This figure depicts roles for membrane-trafficking system machinery under discussion in a generalized eukaryotic cell, based on studies primarily in yeast and mammalian systems. Components are colour-coded, with adaptor proteins (AP, teal), ESCRT (brown), retromer (magenta), and Rab GTPases (orange). Organelles are depicted based on common morphology and labeled in plain text. Arrows, including the directionality of each step, indicate trafficking between organelles. The presence of a dotted line in the interior of phagosomes represents the presence of either a single bounding membrane (phagosomes), or two bounding membranes (autophagosomes). The red oval represents a particle to be phagocytosed. Additional machinery is required for each trafficking event shown, but for simplicity is not included in this diagram. Note that not all organisms perform the illustrated trafficking events (eg. phagocytosis has not yet been reported in apicomplexans or kinetoplastids), and other events occur that are not depicted in this diagram.