Table 1.

Functional homology across model systems.

		A. thaliana		T. thermophila		T. gondii & P. falciparum		G. lamblia		T. brucei		E. histolytica		D. discoideum
Com	Evi	Des	Ref	Des	Ref	Des	Ref	Des	Ref	Des	Ref	Des	Ref	Des	Ref
AP-1	Loc	TGN, endosomes	[40–42]	Puncta	[45]	Golgi, ELC	[46,47]	PV	[50]			Phagosomes	[54]	Phagosomes, Golgi	[55, 56]
	Fxn	Vacuolar delivery, PM recycling	[40–42]			Mic/Rhop biogenesis	[46]	PV trafficking	[50, 51]	Lysosomal delivery	[52,53]			Phagocytosis, CV, lysosomal delivery	[55– 57]
AP-2	Loc	PM, puncta	[59–64]	CV, basal bodies	[45]			PV	[73]			Phagosomes	[54]	PM, CV, puncta	[67, 68]
	Fxn	Endocytosis	[59–62,64]					Endocytosis, cyst formation	[73]
ESCRT	Loc	TGN, endosomes, MVBs	[23,80, 82–85]			Vps4 cytosolic	[95]	PV	[96, 97]	LE/MVB	[78]	Phagosomes, MVBs	[100, 101]	Intracellular puncta	[102]
	Fxn	Vacuolar delivery, autophagy	[82,84–88]							Vacuolar delivery	[78]	Phagocytosis	[101]	Differentiation	[103]
Retromer	Loc	TGN, endosomes	[107–114]	Vps10- like puncta	[120]	TGN,ELC	[122, 123]	PV, ER	[124, 125]	Endosomes	[12]
	Fxn	Vacuolar delivery	[109– 113,115, 116,119]	DCG biogenesis	[120, 121]	ELC to TGN and PM recycling	[122]			Vacuolar delivery	[12]	PPV maintenance	[33, 126]
Rab5	Loc	Endosomes	[131–137]			ELC, PM	[139–144]			Endosomes	[145– 147]	Phagosomes, PPVs	[33, 148, 149]
	Fxn	Vacuolar delivery, recycling	[131,133, 138]			Mic/Rhop and DV trafficking	[139, 143, 144]			Endocytosis	[145– 147]	PPV maintenance	[33]
Rab7	Loc	Endosomes, vacuole	[153]	Phagosomes	[156, 157]	ELC, VAC	[122,123, 139,141, 158]			LE/MVB	[159]	Phagosomes, PPVs	[33, 148]	Phagsosomes, late endocytic	[70, 161– 165]
	Fxn	Vacuolar delivery, autophagy	[153–155]							Vacuolar delivery	[159]	PPV maintenance	[33, 126]	Phagocytosis, lysosomal delivery	[163– 165]
Rab 11	Loc	PM,TGN, endosomes	[168– 170,172, 174–177]	Endosomes	[157]	Rhops, PM (IMC)	[179–181]	Puncta, PM	[182]	Endosomes	[183, 184]	Endosomes, puncta	[185– 187]	CV, phagosomes	[162, 188, 189]
	Fxn	Cytokinesis, PM trafficking	[168–178]			Cell division	[180, 181]	Cyst formation	[182]	Recycling	[183, 184]	Recycling	[187]	CV function, osmotic stress	[188, 189]

This table provides a brief summary of the evidence for functional homology for select membrane trafficking components across discussed model organisms. Trafficking machinery is listed by row and organisms by column. For each component listed, the major localization and presumed function are listed, with appropriate references for each; for more extensive description of the underlying evidence please see the relevant main text section(s).

Abbreviations: Com, component; Evi, evidence; Des, description; Ref, references; Loc, localization; Fxn, function; PM, plasma membrane; TGN, trans-Golgi network; MVB, multi-vesicular body; LE, late endosome; CV, contractile vacuole; DCG, dense core granule; ELC, endosome-like compartment; Mic, microneme; Rhop, rhoptry; VAC, vacuolar compartment; DV, digestive vacuole; IMC, inner membrane complex; PPV, pre-phagosomal vacuole. Blank cells are present where components are either unknown or no evidence exists.