Table 3.
Bivariate and multivariable analysis of the association between HIV-associated immune suppression and death among multidrug-resistant tuberculosis patients in Botswana, 2006 – 2013.
| Variable | Percent of patients who died (n/N) | Bivariate analysis Risk ratio (95% confidence intervals) | Multivariable model Risk ratio (95% confidence intervals) |
|---|---|---|---|
| Sex | |||
| Female | 14.7% (39/265) | 1.00 | 1.00 |
| Male | 24.5% (79/322) | 1.667 (1.178-2.360) | 1.630 (1.041 - 2.553) |
| Age in years | |||
| 15 - 24 | 14.3% (12/84) | 1.00 | |
| 25 - 34 | 15.9% (25/157) | 1.115 (0.591-2.104) | |
| 35 - 44 | 17.4% (29/167) | 1.216 (0.654-2.259) | |
| 45 - 54 | 29.3% (34/116) | 2.052 (1.131-3.721) | |
| ≥55 | 26.4% (14/53) | 1.849 (0.927-3.687) | |
| Age (+10 year) | 1.228 (1.072 - 1.406) | ||
| Prior TB | |||
| No | 4% (1/25) | 1.00 | 1.00 |
| Yes | 20.8% (117/563) | 5.195 (0.756-35.691) | 3.558 (0.493 - 25.664) |
| CD4+ T cell count* | |||
| HIV-uninfected | 15.6% (28/180) | 1.00 | 1.00 |
| <100 | 31.2% (15/48) | 2.009 (1.170-3.448) | 1.890 (1.098 - 3.254) |
| 100 - 199 | 26.6% (17/64) | 1.708 (1.004-2.904) | 1.338 (0.756 - 2.370) |
| 200 - 349 | 16.9% (13/77) | 1.085 (0.595-1.98) | 1.137 (0.634 - 2.036) |
| ≥350 | 12.8% (10/78) | 0.824 (0.421-1.613) | 0.886 (0.441 - 1.781) |
*
Patients with unknown CD4+ T cell counts (n = 141) were excluded from the analysis.