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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Pharmacol Ther. 2016 Sep 13;168:143–157. doi: 10.1016/j.pharmthera.2016.09.008

Table 5.

S1P receptor Antagonists

Antagonist Chemical name Structure Specificity
VPC 23019 (R)-2-amino-3-((3-octylphenyl)amino)- 3-oxopropyl dihydrogen phosphate graphic file with name nihms816689t17.jpg S1PR1 & 3
VPC 23153 (R)-phosphoric acid mono-[2-amino-2- (6-octyl-1H-benzoimiazol-2-yl)-ethyl] ester graphic file with name nihms816689t18.jpg S1PR4
SB 649146 Structure not known S1PR1
BML-241 2-undecyl-thiazolidine-4-carboxylic acid graphic file with name nihms816689t19.jpg S1PR3
JTE 013 N-(2,6-dichloro-4-pyridinyl)-2-[1,3- dimethyl-4-(1-methylethyl)-1H- pyrazolo[3,4-b]pyridin-6-yl]-hydrazinecarboxamide graphic file with name nihms816689t20.jpg S1PR2
W123 3-(2-(3-hexylphenylamino)-2- oxoethylamino) propanoic acid graphic file with name nihms816689t21.jpg S1PR1
VPC 24191 (S)-phosphoric acid mono-[2-amino-3- (4-octyl-phenylamino)-propyl] ester graphic file with name nihms816689t17.jpg S1PR1 & 3