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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Int Forum Allergy Rhinol. 2016 Aug 2;6(12):1273–1283. doi: 10.1002/alr.21826

TABLE 3.

Summary of dietary salicylate avoidance for CRS in AERD

Study Year Study Design LOE Subjects (n) Study Groups Treatment Protocol Primary clinical end-points Conclusion
Sommer DD et al.28 2016 Randomized controlled trial with internal crossover 2 AERD* 30

  1. Low salicylate diet;

  2. Regular diet

 Dietary monitoring × 6 weeks

  1. HRQoL (SNOT-22, NSSS, ACQ-7);

  2. Objective (LKES, POSE)

 Dietary salicylate avoidance is associated with improved HRQoL and validated measures of sinonasal inflammation.

ACQ-7 = Asthma Control Questionnaire-7; AERD = aspirin exacerbated respiratory disease; CRS = chronic rhinosinusitis; HRQoL = health related quality of life; LKES = Lund-Kennedy Endoscopic Score; LOE = level of evidence; NSSS = Nasal Sinus Symptom Scale; POSE = Perioperative Sinus Evaluation; SNOT- 22 = Sino-nasal Outcome Test-22.

*

Presumptive AERD without oral aspirin challenge