Table 7.

Summary of treatment recommendations for the management of CRS in AERD

Treatment strategy	Grade of evidence	Balance of benefit to harm	Recommendation level	Intervention protocol
Dietary salicylate avoidance	N/A	Benefit	Option	Trial of dietary salicylate avoidance may be considered for persistent sinonasal symptoms not controlled by topical corticosteroids or sinonasal irrigations.
Leukotriene modification	B	Equal	Option	Trial of LTMDs may be considered for persistent sinonasal symptoms not controlled by topical corticosteroids or sinonasal irrigations.
Desensitization with daily aspirin therapy	B	Benefit	Recommendation	Desensitization with daily aspirin therapy is recommended as an adjunctive treatment for AERD patients following revision ESS.

AERD = aspirin exacerbated respiratory disease; CRS = chronic rhinosinusitis; ESS = endoscopic sinus surgery; LTMD = leukotriene modifying drugs; N/A = not available.