Skip to main content
. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Pharmacol Ther. 2016 Sep 6;168:126–142. doi: 10.1016/j.pharmthera.2016.09.012

Figure 3. Biophysical simulation has provided both new mechanistic insight and contributed to improved therapeutics in AF.

Figure 3

Computation has provided fundamental understanding of AF mechanisms in terms of the contributions of native atrial heterogeneities, and stage-specific mechanisms as AF progressed from paroxysmal to persistent to permanent (top panel). These insights have enabled improvements to strategies for non-pharmacological rhythm control (summarized in the bottom panel). Notably, biophysical modeling and simulation is a viable strategy for therapy planning in the context of catheter ablation, as discussed in section 3.2.