The cross-neutralizing activities of plasmas from HIV+ individuals were evaluated against the indicated clade A, B and C viruses. The values are the plasma titers at which 50% neutralization (IC50) was recorded. IC50 values are color-coded: (blue) IC50<1:100; (yellow) 1:100≤IC50≥1:250; (red) IC50>1:250. A (−) symbol indicates less than 50% neutralization was recorded. The term ‘breadth’ represents the percent of isolates neutralized by a plasma sample, out of the total number of isolates tested, irrespective of the potency of neutralization. With the exception of SF162.LS, which is a tier 1 virus, all viruses were tier 2.