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. Author manuscript; available in PMC: 2017 Dec 5.
Published in final edited form as: Curr Biol. 2016 Nov 3;26(23):3116–3128. doi: 10.1016/j.cub.2016.09.038

Figure 2. Class II and III sensory neurons are activated by cold.

Figure 2

( (A–D) Representative tracings of class-specific GCaMP6 responses (ΔF/F) with cold stimulation (6 °C) in (A) CI (ddaD, ddaE), (B) CII (ddaB), (C) CIII (ddaA, ddaF), and (D) CIV neurons (ddaC, marked by white arrow). (A–D) White-blue spectrum bar signifies temperature range (25–6 °C). Bottom inserts: neuronal activation at a cold temperature (6 °C) and baseline temperature (25 °C). (E) Average peak change in fluorescence (ΔF/F) ± s.e.m., * = p < 0.01, ** = p < 0.001. (F) Cross-correlation analysis of neuronal activation with respect to temperature. Dashed box: clustered negative cross-correlation values for CIII neurons. (E–F) n = 20 per neuron. See also Figure S2 and Movie S4.