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. Author manuscript; available in PMC: 2016 Dec 9.
Published in final edited form as: Oncogene. 2016 Jun 6;35(49):6341–6349. doi: 10.1038/onc.2016.167

Figure 3. Mtgr1−/− tumors demonstrate dysregulated Wnt signaling.

Figure 3

(a) Venn diagram of MTGR1 and MTG16 genomic occupancy based on ChIP-seq analysis. (b) Fold enrichment of chromatin immunoprecipitation of endogenous MTGR1 and MTG16 in Young Adult Mouse Cells (YAMC). Data is presented as mean ± SEM. All experiments were performed in triplicate. One-way ANOVA analysis with Dunnett’s post-test. (c) Representative images of β-catenin immunohistochemistry and (d) quantification of β-catenin nuclear localization and intensity. Student’s t-test was used for statistical analysis. (e) RNA-seq analysis of Apc1638/+;Mtgr1+/+ (n=3) and Apc1638/+;Mtgr1−/− (n=3) tumors identifying Wnt-perturbed signaling networks. *P<0.05, **P<0.01, ***P<0.001.