Figure 1.

Flow diagram of the study with results of germline mismatch repair gene mutations by pattern of abnormal immunohistochemical expression in the ACCFR.

^† One tumour showed loss of PMS2 and MSH2/MSH6 expression.

^‡ One tumour showed normal expression of MMR proteins but an MSI-H phenotype.

^§ One tumour showed loss of MLH1/PMS2 and MSH6 expression. From the 13 tumours with methylation of MLH1, 8 were also positive for the BRAF^V600E somatic mutation.