Table 2.
Proband characteristics and tumour histological features from the Melbourne Collaborative Cohort Study (MCCS)
| Number (%) | |||
|---|---|---|---|
|
All
(851 CRC, 826 probands) |
MMR-Proficient
(740 CRC, 723 probands) |
MMR-Deficient
(111 CRC, 103 probands) |
|
| Gender | |||
| Female | 398 (48) | 334 (46) | 64 (62) |
| Male | 428 (52) | 389 (54) | 39 (38) |
| Age at diagnosis† (years) | |||
| Median (range) | 70 (41-86) | 69 (42-86) | 72 (41-83) |
| Mean ± Standard deviation | 68.5 ± 8.2 | 68.2 ± 8.2 | 70.3 ± 8.2 |
| 18 – 30 | 0 | 0 | 0 |
| 31 – 40 | 0 | 0 | 0 |
| 41 – 50 | 23 (2.7) | 17 (2.3) | 6 (5.4) |
| 51- 60 | 117 (13.8) | 111 (15) | 6 (5.4) |
| 61- 70 | 327 (38.4) | 291 (39.3) | 36 (32.4) |
| 71-80 | 347 (40.8) | 293 (39.6) | 54 (48.7) |
| >80 | 37 (4.3) | 28 (3.8) | 9 (8.1) |
| Tumour location | |||
| Proximal colon | 301 (37) | 212 (30) | 89 (84) |
| Distal colon | 215 (26) | 208 (29) | 7 (7) |
| Rectum | 299 (37) | 289 (41) | 10 (9) |
| Missing | 36 | 31 | 5 |
| Histological type | |||
| Adenocarcinoma | 749 (90) | 671 (93) | 78 (72) |
| Mucinous carcinoma | 66 (8) | 42 (6) | 24 (22) |
| Signet ring cell carcinoma | 10 (2) | 5 (1) | 5 (5) |
| Undifferentiated | 4 (0) | 3 (0) | 1 (1) |
| Missing | 22 | 19 | 3 |
| Histological grade (adenocarcinoma) | |||
| Low grade | 669 (81) | 605 (84) | 64 (60) |
| High grade | 155 (19) | 113 (16) | 42 (39) |
| Undifferentiated | 4 (0) | 3 (0) | 1 (1) |
| Missing | 23 | 19 | 4 |
| Tumour margin | |||
| Expanding | 522 (71) | 444 (69) | 78 (80) |
| Infiltrating | 214 (29) | 195 (31) | 19 (20) |
| Missing | 115 | 101 | 14 |
| Peritumoural lymphocytes | |||
| Present | 160 (22) | 114 (18) | 46 (46) |
| Absent | 583 (78) | 528 (82) | 55 (54) |
| Missing | 108 | 98 | 10 |
| Crohn's-like reaction | |||
| Present | 130 (18) | 83 (13) | 47 (48) |
| Absent | 593 (82) | 542 (87) | 51 (52) |
| Missing | 128 | 115 | 13 |
| Tumour-infiltrating lymphocytes | |||
| Present | 185 (23) | 113 (16) | 72 (69) |
| Absent | 608 (77) | 576 (84) | 32 (31) |
| Missing | 58 | 51 | 7 |
| BRAFV600E mutation | |||
| Positive | 134 (17) | 74 (11) | 60 (58) |
| Negative | 657 (83) | 613 (89) | 44 (42) |
| Missing | 60 | 53 | 7 |
†
Age at diagnosis of first CRC for metachronous CRC