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. 2016 Jun 6;36(2):194–207. doi: 10.1038/onc.2016.188

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L209P FEN1 interferes with the activity of WT FEN1. (a) FEN activity assay with purified WT and L209P FEN1. (b) EXO activity assay with purified WT and L209P FEN1. (c) GEN activity assay with purified WT and L209P FEN1. In all the panels, the DNA substrate is the same as that used in Figure 2. ³²P labeling of DNA is indicated by *. The left panel shows the PAGE gel separating the DNA substrate and the cleavage products. The graph in the right panel represents quantification analysis of the image in the left panel.