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. 2016 Jun 6;36(2):194–207. doi: 10.1038/onc.2016.188

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Copyright © 2017 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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The FEN1 L209P mutation induces chromosomal instability and cellular transformation. (a) Spontaneous chromosomal breaks in SW480 cells expressing L209P or WT FEN1. Representative Giemsa-stained WT and L209P FEN1-containing SW480 metaphase cells are shown. The right panel represents the percentage of cells containing chromosomal breaks for WT and L209P FEN1-containing SW480 cells. A total of 50 metaphase cells was scored for each cell line. (b) Representative chromosome counting image of WT and L209P FEN1-containing SW480 metaphase cells, showing the chromosomal instability and aneuploidy. A total of 60 metaphase cells was scored for each cell line. (c) Tumorigenesis assay in vivo. The cells (10 million cells per mouse) were injected subcutaneously into 6-week-old female mice. The tumor volume was measured every 3 days. (d) The tumor weights on day 24 are shown.