Figure 2.

The CYP51 clan. A total of 48 sequences in the CYP51 family across all taxa are shown as a Neighbor-Joining tree computed with a PAM350 scoring matrix. In this new nomenclature, subfamilies in CYP51 represent major taxonomic divisions, not the usual ≥55% sequence identity. CYP51H sequences in rice are an exception, apparently diverging from the usual CYP51 function. Abbreviations for the 75 species used in Figures 2 to 6 are as follows: Af, Aspergillus fumigatus; An, Aspergillus nidulans; Ao, Asparagus officinalis; At, Arabidopsis (thale cress); Bf, Botryotinia fuckeliana; Bs, Berberis stolonifera; Ca, Candida albicans; Cd, Candida dubliniensis; Cg, Candida glabrata; Ch, C. reinhardtii (green algae); Ci, Cicer arietinum (chickpea); Cj, Coptis japonica; Cm, Cucurbita maxima (pumpkin); Cr, Catharanthus roseus (Madagascar periwinkle); Ct, Candida tropicalis; Dd, Dictyostelium discoideum (cellular slime mold); Ec, Eschscholzia californica (California poppy); Eg, Erysiphe graminis; El, Euphorbia lagascae; Ga, Gossypium arboreum (cotton); Ge, Glycyrrhiza echinata (licorice); Gg, Gallus gallus (chicken); Gm, soybean; Hs, Homo sapiens (human); Ht, Helianthus tuberosus (Jerusalem artichoke); Io, Issatchenkia orientalis (fungi); Le, tomato; Lj, Lotus japonicus (lotus); Lm, Leishmania major (Leishmaniasis parasite); Lr, Lolium rigidum (ryegrass); Ls, Liquidambar styraciflua (sweetgum); Ma, Mycobacterium avium; Mc, Methylococcus capsulatus; Me, Manihot esculenta (cassava); Mf, Monilinia fructicola; Mm, Mus musculus (mouse); Ms, Medicago sativa (alfalfa); Mt, Mycobacterium tuberculosis; Mu, Musa acuminata (banana); Mys, Mycobacterium smegmatis; Nc, Neurospora crassa; Np, Nicotiana plumbaginifolia; Nt, tobacco; Os, rice; Pa, Persea americana (avocado); Pas, Pastinaca sativa (wild parsnip); Pc, Pyrus communis (pear); Ph, Petunia hybrida; Phc, Phanerochaete chrysosporium (white rot fungus); Pi, Penicillium italicum; Pnc, Pneumocystis carinii; Pr, Pinus radiata (Monterey pine); Ps, pea; Pso, Papaver somniferum (opium poppy); Pt, Pinus taeda (loblolly pine); Rn, Rattus norvegicus (rat); Sa, Sinapis alba (white mustard); Sb, Sorghum bicolor; Sc, yeast; Sm, Solanum melongena cv Sinsadoharanasu (eggplant); Sp, Schizosaccharomyces pombe (fission yeast); St, potato; Ta, wheat; Tc, Taxus cuspidata (Japanese yew); Tm, Triglochin maritima; Tr, T. rubripes (Japanese pufferfish); Trb, Trypanosoma brucei (African sleeping sickness parasite); Trc, Trypanosoma cruzi (Chagas disease parasite); Um, Ustilago maydis; Un, Uncinula necator (grape powdery mildew fungus); Vr, Vigna radiata (mung bean); Vs, Vicia sativa; Vv, Vitis vinifera (grape); Xl, Xenopus laevis (African clawed frog); and Zm, Z. mays (maize).