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Effect of gene dose of mismatched antigen.
| Mismatched antigen | Mean graft survival (years) |
|
|---|---|---|
| Heterozygous | Homozygous | |
| 1 HLA-B | 20.1 | 6.7 |
| 1 HLA-DR | 16.9 | 14.7 |
| 1 each HLA-A, -B, -DR | 15.0 | 13.0 |
| 10-year graft survival (%) | ||
| 1 HLA-B | 85 | 0 |
| 1 HLA-DR | 87 | 67 |
| 1 each HLA-A, -B, and -DR | 84 | 70 |
Homozygosity with two copies of a mismatched antigen, compared to heterozygosity with a single copy, was associated with reduced mean graft survival and 10-year graft survival. Adapted from Kim et al. (12).
